Frequency: Quarterly E- ISSN: Awaited P- ISSN: Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, getCITED, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Infectious Diseases & Immunology (Formerly Inventi Rapid: Infection)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on etiology, pathogenesis, diagnosis and treatment of infectious diseases in outpatient and inpatient settings. Special emphasis is laid on reporting of new resistances and abuses of anti-infective agents.
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) which has spread quickly all over the world. People with diabetes are greater at risk of its complications and of COVID19 related death. Recently, a letter published in the New England Journal of Medicine has announced the establishment of a global registry of new cases of diabetes in COVID-19 patients. Coronavirus expands the danger of confusions as well as it might trigger beginning of diabetes in sound individuals.. In this new examination we found that there may exist a two-route connection between Covid contamination and diabetes. In this we aimed to review the evidence supporting that COVID -19 may trigger onset of diabetes in absolutely healthy people....
Zika virus (ZIKV) is mosquito-borne emerging Flavivirus. Which was first identified in Zika forest at Uganda in 1947 in rhesus monkey. It was caused by a bite of an infected Aedes mosquito. Primarily Aedes aegypti and later Aedes albopictus is also a potential vector of ZIKV, based on data from experimental infections. The virus belongs to family Flaviviridae. Generally 80% of patients with Zika virus is asymptomatic, approximately one person in five who becomes infected with Zika are likely to have symptoms. It is a sexually transmitted virus, it is also transmitted from mother to baby. The main sign with baby infected with this Zika virus is microcephaly. The pathogenesis of flaviviruses (Zika virus) are thought to replicate initially in dendritic cells near the site of inoculation then spread to lymph nodes and the bloodstream and later in cellular cytosol. The epidemiology of Zika is more in continents like Asia and Africa. Zika virus is diagnosed through PCR (polymerase chain reaction). The incubation period is typically 3–12 days. There is no specific therapy for Zika virus infection and acute symptoms typically resolve within 4-7 days. Preventive measures are necessary to stop the spread and transmission of virus especially in case of special population like pregnant women and common public....
The novel coronavirus (COVID-19) known as Severe Acute Respiratory Syndrome coronavirus - 2 (SARS-CoV 2) declared as a pandemic on 11th March 2020. The Symptoms of infection are same as Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). The genomic sequence of novel coronavirus has about 79.6% sequence identity with (SARS-CoV). Random mutations and recombination are the main causes for the genetic diversity of this virus. Coronaviruses have large positive, single stranded RNA genomes with 5′ end capped and 3′ end polyadenylated. The genome is about 30 Kb in length encoding 9860 amino acids. The 5’ end of the genome consists of two large replicase open reading frames like ORF1a and ORF1b that encodes polyproteins PP1ab and PP1a. The polyproteins are then breakdown to yield 16 non-structural proteins which include RNA-dependent RNA polymerase, papain-like proteinase protein, 2'-O-Ribose-Methyltransferase etc., which are involved in viral RNA synthesis. The 3′ end one-third of the genome encode many structural and accessory protein like spike (S) glycoprotein, matrix (M) glycoprotein, envelope (E) protein, nucleocapsid(N) phosphoprotein, they are expressed by a discontinuous transcription process from a set of 5′ leader-containing subgenomic mRNAs. Coronavirus protein synthesis occurs as cap-dependent translation mechanisms and other regulatory mechanisms, like ribosomal frame shifting mechanism. Coronavirus replication affects the process of cellular translation, like activation of stress-induced signalling pathways, releasing viral proteins that inhibit cellular mRNA translation and stability of RNA. More cytokines are produced from highly inflammatory cells which leads to cytokine storm. Cytokine storm and accelerated host immunity response makes disease symptoms more severe during SARS-CoV2 infection. Ribose 2′-O-methylated viral RNA cap supports the virus to escape from host immunity barrier. This topic depicts current scenario of understanding the mechanism of coronavirus mRNA translation, changes in host mRNA translation, induction of Cytokine storm, how the virus escape from host immunity barrier that is observed in corona virus-infected cells....
Mucormycosis is a novel angioinvasive infection caused by the Mucorales order of the Zygomycete class's ubiquitous filamentous fungus. Following candidiasis and aspergillosis, mucormycosis has emerged as the third most common invasive mycosis in patients receiving haematological and allogeneic stem cell transplantation. Mucorales members are extremely rare in nasal mucus, indicating that spores in airway mucus are cleared by mucociliary transport or that there is very little airborne contamination. Disseminated mucormycosis is an uncommon condition that most commonly affects neutropenic individuals with hematologic malignancies, transplant recipients and those on deferoxamine treatment. We present the case of a 64-year-old immunocompetent guy with severe pneumonia and widespread jaundice who died within 24 hours. The autopsy revealed two important findings: severe splenic perforations and several bleeding foci on the pancreas. A histopathological examination of tissue sections indicated the presence of characteristic zygomycetes hyphae in the left lung, pancreas, spleen and brain. The involvement of the pancreas in this patient was one of the few mucormycosis characteristics mentioned in the literature. Our case demonstrates uncommon clinical manifestations of disseminated mucormycosis and emphasises the need of considering disseminated mucormycosis even in immunocompetent individuals....
More than 10 significant outbreaks or epidemic viral breakout incidents occurred in the 21st century, including the continuing deadly coronavirus disease 2019 (COVID-19) plague. Several pathogenic viruses have originated from animals or re-emerged in the past few decades, posing severe hazards to human health and the global financial system. Chikungunya vector-borne diseases, COVID-19, Dengue fever, Ebola, Lassa fever, Marburg hemorrhagic fevers, Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), Swine flu, WestNile fever, Zika and yellow fever examples of zoonotic diseases that have grown over the world and have had such a severe effect on the health that the scientific community has been urged to intervene quickly in screening and managing developing illnesses. Despite amazing advances in scientific understanding, the emergence of new/re-emerging fatal viral diseases has had a profound impact on humans. Emerging viral infections will continue to damage human safety because of world trade, transportation and ecosystem disturbance. Viruses from either zoonotic or vector-borne origins generate the majority of catastrophic risks....
Corona viruses have caused two large-scale pandemics in the past two decades, SARS and Middle East respiratory syndrome (MERS). It has generally been thought that SARS-CoV which is mainly found in bats could cause a future disease outbreak. The novel Corona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of corona viruses that infect humans. On December 31, 2019, the Chinese Center for Disease Control and Prevention (China CDC) dispatched a rapid response team to accompany Hubei provincial and Wuhan city health authorities and to conduct an epidemiologic and etiologic investigation. In this article different invasion and diagnosis of corona virus is dealt with....
An investigation was made on weekly relative body weight gain (RWG) in two strains of Japanese quails, Black (3,438) and Brown (3,710) which were under selection for high 4-week body weight in 8th, 9th and 10th generations. The strain had significant (P<0.01) influence on relative weight gain; Black quails recorded higher relative weight gain (%) of 262.70+1.39, 128.56+0.85, 73.64+0.44 and 44.09+0.31 at first, second, third and fourth week of age respectively. At corresponding ages these values in Brown quails were 248.52+1.30, 120.61+0.80, 70.74+0.41 and 40.47+0.29 respectively. Sex effect was not significant on relative weight gain at all ages. The percentage of relative weight gain in males were 284.60+1.35, 123.64+0.83, 77.79+0.43 and 44.03+0.31, whereas in females these values were 256.62+1.29, 125.52+0.79, 71.58+0.41 and 44.53+0.29 respectively. Effect of Generation was significant on rate gain and highest weight gain was observed in ninth generation. Hatch effect was found to be significant on RWG but no specific trend was observed....
Arboviral diseases are caused by bite of infectious arthropod, mostly mosquitoes and ticks. Conventionally, less importance has been given to arboviral research. In past 50 years, the occurrence of epidemic arboviral diseases such as dengue, yellow fever, zika virus infection has changed insights about their impact to worldwide disability and mortality. Throughout the world and in the United States arboviral infections are increasingly major causes of neurological diseases. Zika infection disease is latest illustration, which moved quickly from lack of definition to a Public Health Emergency of global concern. In worldwide out of 390 million infections, 100 million are symptomatic. This article reviews the major arboviral infections mainly caused by aedes species that causes various health issues as, vaccines are available for some disease and others are in research. The authors focused on various prevention methods and ayurvedic remedies for treatment of infectious diseases....
A neglected disease originated from Wuhan (China) conquered whole world with doubt and fear. The current outbreak of viral of COVID-19 (2019-nCoV) quaked world with fear of economic and healthcare disturbances. The risk of further spread compelled the World Health Organization (WHO) to declare it as a national emergency and other countries obligated the decision with the provincial lockdown. In the present review, we have discussed the various aspects of pandemic spreads, its historical context and the latest investigations demonstrating the current scenario of COVID-19 in the world. In addition, we have highlighted the various aspects regarding the COVID-19 like preparedness and necessary aspects which will help for risk assessment and crisis management. Rapid sharing scientific information is an effective way to implement awareness and response. Thus, providing frontline aspects helpful for epidemiologists and scholars which will further benefit the research fraternity as real-time guidance....
Aim of this research was to identify, monitor and evaluate the sepsis and septic shock among in-patients. A total of 110 subjects were enrolled based on inclusion and exclusion criteria and are diagnosed with sepsis and septic shock, of which most of them were suffering from infectious comorbidities. This shows the percentage prevalence of septic shock in patients with hypertension is 31.3%. Patients were found to show various co- morbidities. Both gram-positive bacteria and gram-negative bacteria are responsible for sepsis and septic shock in which the common organism affecting this condition is the Klebsiella 6.36% and Streptococcus aureus 4.54%, Whereas E. coli shows drastically increased rate 5.45% in urosepsis condition. The conclusion shows the probability of encountering a subject with septic shock along with co-morbid conditions is 6.36%. Evidence-based international guidelines are of great value to treat the condition correctly, they help in reducing the health-care-associated conditions. The major cornerstone toward risk reduction is to be aware and abreast of the latest guidelines and be keen on implementing at the hour of need....
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